Bursting activity of striatal medium spiny neurons results from membrane potential
oscillations between a down-and an upstate that could be regulated by G-protein-coupled
receptors. Among these, dopamine D 2 and adenosine A 2A receptors are highly enriched
in striatal neurons and exhibit strong interactions whose physiological significance and
molecular mechanisms remain partially unclear. More particularly, respective involvements
of common intracellular signaling cascades and A 2A–D 2 receptor heteromerization remain …